Sonic the neurotransmitter

Scientists at Toronto Western Hospital have discovered the function of a long-mysterious brain chemical -- which might help them prevent Parkinson's Disease. It's a neurotransmitter, something that helps to manage communication between brain and nerve cells; Parkinson's patients don't have enough of this chemical in their brains. This finding is considered to be quite a significant breakthrough.
And the name of the mystery neurotransmitter? "Sonic Hedgehog."
The hospital issued a press release to Canada NewsWire, which is simply breathtaking in its weirdness. To quote:
The findings suggest that increasing the amount of Sonic Hedgehog in the brain may be a potential treatment for Parkinson's disease. ...
"The research demonstrates that Sonic Hedgehog plays a surprising role in the brain's control of body movement," says Dr. Jonathan Brotchie, senior scientist with Toronto Western Research Institute, the research arm of Toronto Western Hospital.
"More importantly, we have shown that this function of Sonic Hedgehog is reduced in Parkinson's disease, and that this reduction may be one of the causes of Parkinson's disease."
Apparently, scientists discovered this mystery gene seven years ago or so, and gave it the video-game nickname. Who knew? At any rate, a Google search for "sonic hedgehog neuroscience" produces a blizzard of equally bizarre medical citations, such as this lovely bit of prose from Columbia University Health Sciences:
Starting with mouse embryonic stem cells growing in vitro, the scientists sequentially added two signaling proteins known to differentiate neural cells in vivo. Retinoic acid stimulated the formation of spinal cord cells and, then, sonic hedgehog changed the cord cells to spinal motor neurons.
(Thanks to Sean for pointing this one out!)
Posted by Clive Thompson at October 02, 2003 04:18 PM
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Maybe someone who has more of a bio background than me can help, but I believe the first gene found in this family was 'hedgehog', possibly because of a phenotype. Some witty molecular biologist then named a related gene 'sonic' (this was some years ago, obviously). The 'sonic hedgehog' mentioned in the article is presumably the protein that this gene codes for. Odds are, the scientists who named the gene never dreamed that the protein would turn out to be useful and the name would stick for it as well as the gene.
Then again, maybe they did.